Precision DLS Systems for Nanoparticle & Molecular Size Analysis

Advanced dynamic light scattering solutions for accurate characterization of particles, polymers, and proteins in B2B life science workflows.

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Precision Particle Analysis with Dynamic Light Scattering (DLS)

Dynamic Light Scattering (DLS) is a highly sensitive analytical technique used to measure the hydrodynamic size, size distribution, and zeta potential of nanoparticles, proteins, and polymers in solution. By analyzing fluctuations in scattered light intensity caused by Brownian motion, DLS enables real-time, non-invasive particle characterization at the nanoscale. It plays a critical role in formulation development, nanomedicine, vaccine stability, and quality control.

Physi Analytica offers DLS systems tailored to the evolving demands of B2B clients across North America. With precise laser optics, robust thermal control, and automated data analysis, our platforms ensure consistency and reproducibility in both research and industrial environments. Our expertise supports labs working with complex biological samples and delicate nano formulations—delivering accurate insights through intuitive systems, engineered for compliance and scalability.

Core Components of DLS Systems

In addition to offering products and systems developed by our team and trusted partners for Dynamic Light Scattering (DLS), we are proud to carry top-tier technologies from Global Advanced Operations Tek Inc. (GAO Tek Inc.) and Global Advanced Operations RFID Inc. (GAO RFID Inc.). These reliable, high-quality products and systems enhance our ability to deliver comprehensive technologies, integrations, and services you can trust. Where relevant, we have provided direct links to select products and systems from GAO Tek Inc. And GAO RFID Inc.

  • High-precision sensors (optical, electrochemical, infrared) — used in DLS systems for detecting nanoscale particle movement, integrated with us Optical & Imaging Sensors to ensure precise photon detection and signal clarity.
  • Embedded processors with AI chipsets — for real-time particle analysis and data computation in DLS instruments, powered by Device Edge solutions to maximize processing speed at the source.
  • Modular housings for environmental protection — provide durability and flexibility in varied lab conditions, supported by Industrial & Asset Monitoring Sensors for performance tracking and housing condition awareness.
  • Data acquisition modules and built-in calibration features — enable seamless sample analysis and validation in DLS workflows, enhanced with BLE Gateways, Beacons & Accessories for reliable wireless calibration sync and status transmission.
  • Wireless and Ethernet-enabled communication ports — allow fast and secure instrument communication in distributed DLS setups, supported by Wi-Fi HaLow End Devices, ideal for high-efficiency, long-range data transfer in lab environments.
  • Particle size distribution visualization with automated data validation
  • Zeta potential analysis and Debye length calculation
  • Batch processing tools for multi-sample studies
  • Regulatory-compliant data management and digital access control
  • Multi-user license support and cloud synchronization options
  • Remote DLS data access and visualization dashboards
  • Real-time alerts on instrument status and drift
  • Secure multi-location sample comparison tools
  • Long-term encrypted storage for FDA-ready audit trails
  • AI-powered size clustering and classification algorithms
  • Measures particle sizes from <1 nm to several microns
  • Simultaneous determination of zeta potential and polydispersity index (PDI)
  • Temperature-controlled sample handling for consistent readings
  • Non-destructive analysis ideal for fragile nano formulations
  • Intuitive, touchscreen-operated interfaces for quick training and deployment
  • Compatible with UV/Vis and multi-angle light scattering (MALS) systems
  • Easy connection to LIMS and electronic lab notebooks (ELNs)
  • Barcode integration for sample tracking
  • USB, Bluetooth, and Wi-Fi-based communication ports
  • Data export in CSV, XML, PDF, and proprietary formats
  • Accelerated nanoparticle characterization for R&D and QA/QC
  • Improved reproducibility and inter-lab data consistency
  • Reduced sample consumption and preparation time
  • Early detection of aggregation and instability in formulations
  • Supports both dilute and concentrated sample measurements
  • Liposome and nanoparticle drug delivery characterization
  • Protein aggregation and formulation stability studies
  • Polymer size and PDI measurement
  • Viral particle sizing and vaccine development
  • Environmental monitoring of colloidal contaminants
  • Biopharmaceuticals and Vaccinology
  • Materials Science and Polymer Chemistry
  • Nanotechnology and Particle Engineering
  • Environmental Safety and Water Testing
  • Food Quality Control and Nutraceutical
  • Relevant U.S. & Canadian Standards
  • USP <729> Globule Size Distribution
  • ISO 22412 Particle Size Analysis – DLS Method
  • 21 CFR Part 11 (FDA Compliance)
  • Health Canada GLP Compliance
  • ASTM E2490-09 Light Scattering for Nanomaterials
  • FDA 21 CFR Part 11 
  • ISO/IEC 17025 – Testing & calibration laboratories 
  • USP General Chapter <729> – Globule size distribution testing 
  • CEPA (Canadian Environmental Protection Act) – Nanomaterial regulations 
  • NIST Nanotechnology Standards – Particle size and zeta potential measurement 

Case Studies

United States (Vaccine Formulation R&D)

A U.S.-based biotech company used our DLS platform to optimize liposomal particle size and charge stability in mRNA vaccine formulations. The system’s automated analysis and temperature precision reduced formulation development time by 25%.

United States (Environmental Testing Lab)

An independent lab utilized our DLS solutions to monitor nanoparticle contaminants in municipal water supplies. Through cloud integration and automated batch reporting, the team enhanced regulatory traceability and data transparency.

Canada (University Nanomedicine Lab)

A leading Canadian academic center deployed Physi Analytica’s DLS technology to evaluate nano emulsions in drug delivery. The integrated temperature module and real-time cloud access improved collaboration across research teams.

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Have questions about Dynamic Light Scattering systems?

Reach out to us today for tailored consultation, product demos, or integration support. Our team is ready to help elevate your particle analysis with precision tools and expert service. for tailored consultation, product demos, or integration support. Our team is ready to help elevate your particle analysis with precision tools and expert service.

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