Precision Isothermal Titration Calorimetry Systems for Binding Analysis

Explore advanced ITC solutions for accurate thermodynamic
profiling of molecular interactions in research and industry.

Unmatched Thermodynamic Insights with Isothermal Titration Calorimetry (ITC)

Isothermal Titration Calorimetry (ITC) is a gold-standard technique for directly measuring the thermodynamics of molecular interactions without the need for labeling. By quantifying heat released or absorbed during binding events, ITC provides key insights into affinity, stoichiometry, enthalpy, and entropy. It is widely employed in biopharmaceutical development, protein-ligand studies, drug design, and academic research due to its unmatched sensitivity and label-free operation.

As a trusted B2B provider across North America, Physi Analytica deliver state-of-the-art ITC systems designed to meet regulatory demands, enhance throughput, and support rigorous data accuracy. Backed by robust technical support and expertise, we empower laboratories to streamline discovery workflows with scalable, AI-enhanced analyzers.

Core Components of ITC Systems

In addition to offering products and systems developed by our team and trusted partners for Isothermal Titration Calorimetry (ITC), we are proud to carry top-tier technologies from Global Advanced Operations Tek Inc. (GAO Tek Inc.) and Global Advanced Operations RFID Inc. (GAO RFID Inc.). These reliable, high-quality products and systems enhance our ability to deliver comprehensive technologies, integrations, and services you can trust. Where relevant, we have provided direct links to select products and systems from GAO Tek Inc. And GAO RFID Inc.

Hardware

High-Precision Sensors (optical, electrochemical, infrared)
Used in calorimetric cells for accurate thermal measurements, supported by our Optical & Imaging Sensors category—ensuring thermal detection sensitivity during biomolecular interaction assays.

Embedded Processors with AI Chipsets
Enable real-time data analysis and thermal profile recognition; integrated via our Edge Computing solutions for smarter molecular interaction analysis.

Modular Housings for Environmental Protection
Ensure thermal insulation and contamination-free titrations, leveraging our Environmental & Agriculture Sensors for optimal chamber control.

Data Acquisition Modules and Built-in Calibration Features
Improve accuracy and reproducibility of binding enthalpy calculations, supported by our Temperature Data Loggers product category.

Wireless and Ethernet-Enabled Communication Ports
Allow seamless integration with lab networks and LIMS through our IoT Platforms, enabling fast, secure, and compliant data access.

Software

AI-driven curve fitting and thermodynamic data analysis.
Real-time visualization of titration curves and heat maps.
Automated baseline correction and noise filtering.
Cross-platform compatibility with APIs for integrations.
Regulatory compliance with FDA 21 CFR Part 11 and ISO/IEC 17025.

Cloud Services

Encrypted cloud storage with automated backups.
Collaborative portals for data sharing across labs.
Scalable cloud computing for large dataset analysis.
AI-powered predictive insights for binding interactions.
IoT-enabled remote monitoring via web and mobile dashboards.
Flexible subscription tiers for academic, biotech, and pharma teams.

Key Features and Functionalities

Label-free and real-time thermodynamic measurements
Determination of binding constants, enthalpy, entropy, and stoichiometry
Automated syringe-based titration and cell cleaning
High signal-to-noise ratio with ultra-sensitive microcalorimeters
Scalable to high-throughput screening workflows
Integrated temperature control and feedback loops

Integrations and Compatibility

Compatible with most modern LIMS and ELN systems
Seamless connection to analytical data management platforms
USB and Ethernet-based remote operation
GAO RFID-compatible for traceability in B2B and GMP environments
Configurable APIs for AI-assisted assay optimization

Benefits

Eliminates need for sample labeling or immobilization
Provides complete thermodynamic profiling in one experiment
Enhances decision-making in drug development and protein research
Reduces experimental variability with automated controls

Applications

Drug discovery and optimization
Protein-protein and protein-ligand interaction studies
Antibody-antigen characterization
DNA/RNA binding research
Enzyme kinetics and inhibition
Biotherapeutic formulation stability

Industries Served

Biopharmaceutical companies
Academic and government research institutions
Clinical and diagnostics labs
Food safety and quality testing
Environmental monitoring and life sciences
S. & Canadian Industry Standards and Regulations
S. FDA 21 CFR Part 11
ISO/IEC 17025
USP <1058> Analytical Instrument Qualification
Health Canada GLP Compliance
Canadian Biosafety Standards (CBS)

Relevant U.S. & Canadian Standards

FDA 21 CFR Part 58
ICH Q2(R2)
USP General Chapter <1251>
ISO 13485
Health Canada Food and Drug Regulations

Case Studies

U.S. Biotech Firm Accelerates Drug Candidate Validation

A California-based biotech company integrated our AI-enhanced ITC platform into its drug discovery pipeline. The system improved thermodynamic data capture and reduced experiment turnaround time by 35%, aiding preclinical decision-making with greater confidence.

U.S. Academic Lab Boosts Research Throughput

A leading university research lab in Massachusetts upgraded to an automated ITC system from our portfolio. This enhancement enabled simultaneous characterization of multiple biomolecular interactions, reducing manual work and expanding publication-ready results.

Canadian Vaccine Developer Improves Binding Assay Efficiency

A Toronto-based biopharma firm incorporated our ITC hardware to analyze antigen-antibody binding kinetics. Using integrated AI edge processing, they improved assay reproducibility and cut analysis time by 40%, ensuring consistent outcomes for regulatory submissions.

Contact Us

Looking to enhance your molecular binding studies with precision calorimetry? Reach out to us today for expert consultation, technical specs, or live product demos.