Precision CD Spectroscopy Solutions for Secondary Structure Analysis

Advanced circular dichroism spectroscopy tools for protein and
biomolecule characterization across life sciences and biotech.

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Advanced Circular Dichroism (CD) Spectroscopy Systems

Circular Dichroism (CD) Spectroscopy is a powerful technique used to study the secondary structure and conformational changes of chiral molecules, particularly proteins and nucleic acids. By measuring the differential absorption of left- and right-handed circularly polarized light, researchers gain valuable insights into folding, stability, and interactions at the molecular level.

CD Spectroscopy is crucial for structural biology, protein formulation, and biosimilar development. Its applications span from academic research to biopharmaceutical quality control.At Physi Analytica, we provide state-of-the-art CD Spectroscopy technologies and services to B2B clients across North America. As a leading provider, we offer integrated solutions combining reliable instrumentation, expert guidance, and scalable systems tailored for industry needs.

Core Components of Circular Dichroism (CD) Spectroscopy

In addition to offering products and systems developed by our team and trusted partners for CD Spectroscopy, we are proud to carry top-tier technologies from Global Advanced Operations Tek Inc. (GAO Tek Inc.) and Global Advanced Operations RFID Inc. (GAO RFID Inc.). These reliable, high-quality products and systems enhance our ability to deliver comprehensive technologies, integrations, and services you can trust. Where relevant, we have provided direct links to select products and systems from GAO Tek Inc. And GAO RFID Inc.

  • High-precision sensors (optical, electrochemical, infrared) – Ensure accurate light measurement during spectral analysis. Optical & Imaging Sensors ideal for enhanced signal fidelity in CD Spectroscopy.
  • Embedded processors with AI chipsets – It support real-time signal correction and baseline calibration. Device Edge powers intelligent local data processing in spectroscopy systems.
  • Modular housings for environmental protection – It guard sensitive optical systems from external variability. Environmental & Agriculture Sensors for ruggedized protection in lab and field settings.
  • Data acquisition modules and built-in calibration – features streamline measurement workflows and improve repeatability. Temperature Data Loggers for calibrated environmental monitoring and sample tracking.
  • Wireless and Ethernet-enabled communication ports – It facilitate seamless data transfer to connected infrastructure. Wi-Fi HaLow Gateways/Routers  for low-power, long-range connectivity in spectroscopy labs.
  • Intuitive control software for spectral acquisition and calibration
  • Automated secondary structure estimation tools
  • Real-time visualization and baseline normalization
  • API-ready platforms for third-party integration
  • Secure cloud-based storage for spectral data
  • Remote access and monitoring from any connected device
  • Encrypted data transfer for compliance with industry regulations
  • Scalable infrastructure for collaborative data sharing
  • High signal-to-noise ratio for enhanced structural resolution
  • Real-time scanning and baseline correction
  • Wide spectral range coverage (190–250 nm for far-UV, up to 320–350 nm for near-UV)
  • Multi-sample loading capabilities
  • Integrated temperature control modules
  • Support for kinetic and thermal melt studies
  • Compatible with HPLC, UV-Vis, and fluorescence spectrometers
  • Integrates with LIMS and ELN systems for traceability
  • Supports automation through robotic sample handlers
  • Modular upgrades for temperature, cuvette path length, and data interfaces
  • Non-destructive analysis of biomolecular conformation
  • Rapid screening of protein folding and misfolding
  • High sensitivity for small sample volumes
  • Reliable data reproducibility for regulatory compliance
  • Enhanced throughput with automation-ready options
  • Protein secondary structure determination
  • Antibody and biosimilar formulation
  • Peptide-ligand binding interaction studies
  • Drug delivery system analysis
  • Nucleic acid folding and hybridization
  • Biopharmaceuticals
  • Life sciences research
  • Biotech and CROs
  • Food and nutraceuticals
  • Academic and clinical labs
  • S. & Canadian Industry Standards (Selected)
  • ASTM E693-94 (Standard Practice for CD Spectroscopy)
  • FDA 21 CFR Part 11 (Electronic Records & Signatures)
  • Health Canada GUI-0069 (Good Manufacturing Practices)
  • USP <1040> and <1090>
  • ISO 17025
  • FDA 21 CFR Part 312 
  • ICH Q5E 
  • USP General Chapter <1047> 
  • ISO/IEC 17065 
  • Health Canada Guidance for Protein Characterization 

Case Studies

U.S. Biopharma Structural Integrity Validation

A major U.S.-based biopharmaceutical company used our CD Spectroscopy tools for biosimilar comparability assessments. Our systems improved their structural characterization workflow by 30%, supporting faster IND submission.

U.S. University Lab Deployment

A leading biomedical research institution integrated our CD Spectroscopy unit with their protein expression workflow, enabling real-time conformational tracking and improving reproducibility across experiments.

Canadian Biosimilar Product Approval

A Toronto-based life sciences company partnered with us to deploy a modular CD Spectroscopy system for their biosimilar development pipeline. The solution provided robust secondary structure validation aligned with Health Canada GMP standards.

Contact Us

Contact us today to discuss your application, request a demo, or speak with a technical expert. Let’s power your discovery with precision tools you can trust. today to discuss your application, request a demo, or speak with a technical expert. Let’s power your discovery with precision tools you can trust.

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